Trained immunity is an evolutionarily ancient protective mechanism against infection, in which epigenetic and metabolic alterations confer non-specific hyperresponsiveness of innate immune cells to various stimuli. 3Department of Biostatistics and Systems Biology, School of Public Health, Sun Yat-sen University, Shenzhen, Chinaĭysregulated inflammation involving innate immune cells, particularly of the monocyte/macrophage lineage, is a key contributor to the pathogenesis of Duchenne muscular dystrophy (DMD).2Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.1Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada. Petrof 1,2* Tom Podolsky 1,2 Salyan Bhattarai 1,2 Jiahui Tan 3 Jun Ding 1,2
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